Structure of PDB 8hhl Chain A Binding Site BS05

Receptor Information
>8hhl Chain A (length=592) Species: 56689 (Mycolicibacterium mucogenicum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTTMTVHTMGVHYKWQIPEVLRQQLWLAHNLREDLVSLQLAYDDDLKAIW
SSYPDVAQAEDTMAAAEADAVALSERVKQARIEARSKKISTELTQQLRDA
KKRLKDARQARRDAIAVVKDDAAERRKARSDQLAADQKALYGQYCRDGDL
YWASFNTVLDHHKTAVKRIAAQRASGKPATLRHHRFDGSGTIAVQLQRQA
GAPPRTPMVLADEAGKYRNVLHIPGWTDPDVWEQMTRSQCRQSGRVTVRM
RCGSTDGQPQWIDLPVQVHRWLPADADITGAELVVTRVAGIYRAKLCVTA
RIGDTEPVTSGPTVALHLGWRSTEEGTAVATWRSDAPLDIPFGLRTVMRV
DAAGTSGIIVVPATIERRLTRTENIASSRSLALDALRDKVVGWLSDNDAP
TYRDAPLEAATVKQWKSPQRFASLAHAWKDNGTEISDILWAWFSLDRKQW
AQQENGRRKALGHRDDLYRQIAAVISDQAGHVLVDDTSVAELSARAMERT
ELPTEVQQKIDRRRDHAAPGGLRASVVAAMTRDGVPVTIVAAADFTRTHS
RCGHVNPADDRYLSNPVRCDGCGAMYDQDRSFVTLMLRAATA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8hhl Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8hhl Mechanistic and evolutionary insights into a type V-M CRISPR-Cas effector enzyme.
Resolution2.87 Å
Binding residue
(original residue number in PDB)		H549 C552 C569 C572
Binding residue
(residue number reindexed from 1)		H549 C552 C569 C572
Annotation score4
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8hhl, PDBe:8hhl, PDBj:8hhl
PDBsum8hhl
PubMed37460897
UniProtP0DXB1|CS12M_MYCMU CRISPR-associated DNA-binding protein Cas12m (Gene Name=cas12m)

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