Structure of PDB 8gna Chain A Binding Site BS05

Receptor Information
>8gna Chain A (length=1188) Species: 237368 (Candidatus Scalindua brodae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNITVELTFFEPYRLVEWFDWDARKKSHSAMRGQAFAQWTWKGRTAGKSF
ITGTLVRSAVIKAVEELLSLNNGKWEGVPCCNGSFQTDKKPSFLRKRHTL
QWQANICDKEEACPFCILLGRFDNAGKERNKDYDIHFSNFDLDDLRLVDI
ASGRILNRVDFDTGKAKDYFRTWEADYETYGTYTGRITLRNEHAKKLLLA
SLGFVDKLCGALCRIEVIHNDELRKQAEVIVEAFKQNDKLEKIRILADAI
RTLRLHGEGVIEKDELPDGKEERDKGHHLWDIKVQGTALRTKLKELWQSN
KDIGWRKFTEMLGSNLYLIYKKETSDLFIPVTPPEGIETKEWIIVGRLKA
ATPFYFGVQQPSDSIPGEHASFNILLDKENRYRIPRSALRGALRRDLRTA
FGSGCNVSLGGQILCNCKVCIEMRRITLKDSVSDFSEPPEIRYRIAKNPG
TATVEDGSLFDIEVGPEGLTFPFVLRYRGHKFPEQLSSVIRYWEENDGKN
GMAWLGGLDSTGKGRFALKDIKIFEWDLNQKINEYIKERGMRGKEKELLE
MLPDGLIPYKFFEERECLFPYKENLKPQWSEVQYTIEVGSPLLTADTISA
LTEPGNRAAIAYKKRVYNDGNNAIEPEPRFAVKSETHRGIFRTAVGRRTG
DLGKEDHEDCTCDMCIIFGNEHESSKIRFEDLELINGNEFEKLEKHIDHV
AIDRFTGGALDKAKFDTYPLAGSPKKPLKLKGRFWIKKGFSGDHKLLITT
ALSDIRDGLYPLGSKGGVGYGWVAGISIDDNVPDDFKEMIINNDYVHPGH
QSPKQDNIYYPHYFLDSGSKVYREKDIITHEEFTEELLSGKINCKLETLT
PLIIPDTSDENGLKLQGNKPGHKNYKFFNINGELMIPGSELRGMLRTHFE
ALTKSCFAIFGEDSTLKTLGGKLDKALHPCTGLSDGLCPGCHLFGTTDYK
GRVKFGFAKYENGPEWLITRGNNPERSLTLGVLESPRPAFSIPDDESEIP
GRKFYLHHNGWRIIRQKQLEIRETVQPERNVTTEVMDKGNVFSFDVRFEN
LREWELGLLLQSLDPGKNIAHKLGKGKPYGFGSVKIKIDSLHTFKIKRVP
QSDIREYINKGYQKLIEWLPQWHVIPHIDKLYKLLWVPFLLEPDVRYPVL
NEESKGDYTYKKLGDKDNLPYKTRVKGLTTPWSPWNPF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8gna Chain A Residue 1803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8gna Target RNA-guided protease activity in type III-E CRISPR-Cas system.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H747 C750 C752 C755
Binding residue
(residue number reindexed from 1)		H657 C660 C662 C665
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:8gna, PDBe:8gna, PDBj:8gna
PDBsum8gna
PubMed36484100
UniProtA0A0B0EGF3

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