Structure of PDB 8c4v Chain A Binding Site BS05

Receptor Information
>8c4v Chain A (length=1308) Species: 11602 (Hantaan virus 76-118) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YIPDYKGMEPIGANIEDLVDYSKDWLSRARNFSFFEVKGTAVFECFNSNE
ANHCQRYPMSRKPRNFLLIQCSLITSYKPATTLSDQIDSRRACSYILNLI
PDTPASYLIHDMAYRYINLTREDMINYYAPRIQFKQTQNVREPGTFKLTS
SMLRAESKAMLDLLNNQIESLNIASHIVQSESVSLITKILSDLELNITTV
LDKFFQNETQKYLIDVLKKTTAWHIGHLIRDITESLIAHSGLKRSKYWSL
HSYNNGNVILFILPSKSLEVAGSFIRFITVFRIGPGLVDKDNLDTILIDG
DSQWGVSKVMSIDLNRLLALNIAFEKALIATATWFQYYTEDQGQFPLQYA
IRSVFANHFLLAICQKMKLCAIFDNLRYLIPAVTSLYSGFPSLIEKLFER
PFKSSLEVYIYYNIKSLLVALAQNNGVYPSFMSRIVYKHYRSLISEVTTC
FFLFEKGLHGNMNEEAKIHLETVEWALKFREKEEKYGESLVENGYMMWEL
RANAELAEQQLYCQDAIELAAIELNKVLATKSSVVANSILSKNWEEPYFS
QTRNISLKGMSGQVQEDGHLSSSVTIIEAIRYLSNSRHNPSLLKLYEETR
EQKAMARIVRKYQRTEADRGFFITTLPTRCRLEIIEDYYDAIAKNISEEY
ISYGGEKKILAIQGALEKALRWASGESFIELSNHKFIRMKRKLMYVSADA
TKWSPGDNSAKFRRFTSMLHNGLPNNKLKNCVIDALKQVYKTDFFMSRKL
RNYIDSMESLDPHIKQFLDFFPDGHHGEVKGNWLQGNLNKCSSLFGVAMS
LLFKQVWTNLFPELDCFFEFAHHSDDALFIYGYLEPVDDGTDWFLFVSQQ
IQAGHLHWFSVNTEMWKSMFNLHEHILLLGSIKISPKKTTVSPTNAEFLS
TFFEGCAVSIPFVKILLGSLSDLPGLGYFDDLAAAQSRCVKALDLGASPQ
VAQLAVALCTSKVERLYGTAPGMVNHPAAYLQVKHTDTPIPLGGNGAMSI
MELATAGIGMSDKNLLKRALLGYSHKRQKSMLYILGLFKFLMKLSDETFQ
HERLGQFSFIGKVQWKIFTPKSEFEFADMYTSKFLELWSSQHVTYDYIIP
KGRDNLLIYLVRKLNDPSIVTAMTMQSPLQLRFRMQAKQHMKVCRLDGEW
VTFREVLAAANSFAENYSATSQDMDLFQTLTWKDFLNGIHCDVIPTKQVQ
RAKVARTFTVRESIPAVIGYKFAVTVEEMSDVLDTAKFPDSLSVDLKTMK
DGVYRELGLDISLPDVMKRIAPMLYKSRVVIVQGNVEGTAEAICRYWLKS
MSLVKTIR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8c4v Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication.
Resolution3.14 Å
Binding residue
(original residue number in PDB)		P304 A305 T306 T307 Y353 P355 R356 Q460 I464 K468 W473 H477 R480 A488 G491 R494 L1231 S1234 R1238 A1243 P1244 G1245 M1246 F1406 A1410 H1413 M1414
Binding residue
(residue number reindexed from 1)		P79 A80 T81 T82 Y128 P130 R131 Q210 I214 K218 W223 H227 R230 A238 G241 R244 L958 S961 R965 A970 P971 G972 M973 F1133 A1137 H1140 M1141
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004519 endonuclease activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044220 host cell perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c4v, PDBe:8c4v, PDBj:8c4v
PDBsum8c4v
PubMed37221161
UniProtP23456|L_HANTV RNA-directed RNA polymerase L (Gene Name=L)

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