Structure of PDB 7zz8 Chain A Binding Site BS05

Receptor Information

>7zz8 Chain A (length=1057) Species: 1358 (Lactococcus lactis)

HMKKLLVANRGEIAVRVFRACNELGLSTVAVYAREDEYSVHRFKADESYL
IGQGKKPIDAYLDIDDIIRVALESGADAIHPGYGLLSENLEFATKVRAAG
LVFVGPELHHLDIFGDKIKAKAAADEAKVPGIPGTNGAVDIDGALEFAKT
YGYPVMIKAALGGGGRGMRVARNDAEMHDGYARAKSEAIGAFGSGEIYVE
KYIENPKHIEVQILGDRHGNIIHLHERDCSVQRRNQKVIEIAPAVGLSPD
FRNEICEAAVKLCKNVGYVNAGTVEFLVKDDKFYFIEVNPRVQVEHTITE
LITGVDIVQAQILIAQGKDLHREIGLPAQSEIPLLGSAIQCRITTEDPQN
GFLPDTGKIDTYRSPGGFGIRLDVGNAYAGYEVTPYFDSLLVKVCTFANE
FSDSVRKMDRVLHEFRIRGVKTNIPFLINVIANENFTSGQATTTFIDNTP
SLFNFPRLRDRGTKTLHYLSMITVNGFPGIENTEKRHFEEPRQPLLNLEK
KKTAKNILDEQGADAVVDYVKNTKEVLLTDTTLRDAHQSLLATRLRLQDM
KGIAQAIDQGLPELFSAEMWGGATFDVAYRFLNESPWYRLRKLRKLMPNT
MFQMLFRGSNAVGYQNYPDNVIEEFIRVAAHEGIDVFRIFDSLNWLPQME
KSIQAVRDNGKIAEATICYTGDILDPSRPKYNIQYYKDLAKELEATGAHI
LAVKDMAGLLKPQAAYRLISELKDTVDLPIHLHTHDTSGNGIITYSGATQ
AGVDIIDVATASLAGGTSQPSMQSIYYALEHGPRHASINVKNAEQIDHYW
EDVRKYYAPFEAGITSPQTEVYMHEMPGGQYTNLKSQAAAVGLGHRFDEI
KQMYRKVNMMFGDIIKVTPSSKVVGDMALFMIQNDLTEEDVYARGNELNF
PESVVSFFRGDLGQPVGGFPEKLQKIIVKDKAVITDRPGLHAEKVDFETV
KADLEQKIGYEPGDHEVISYIMYPQVFLDYQKMQREFGAVTLLDTPTFLH
GMRLNEKIEVQIEKGKTLSIRLDEIGEPDLAGNRVLFFNLNGQRREVVIN
DQSVQAQ

Ligand information

• Ligand ID: PYR
• InChI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)
• InChIKey: LCTONWCANYUPML-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.385: CC(=O)C(O)=O
  OpenEye OEToolkits 1.7.6: CC(=O)C(=O)O
  ACDLabs 12.01: O=C(C(=O)O)C
• Formula: C3 H4 O3
• Name: PYRUVIC ACID
• ChEMBL: CHEMBL1162144
• DrugBank: DB00119
• ZINC: ZINC000001532517
• PDB chain: 7zz8 Chain A Residue 1206

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7zz8 CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase.
• Resolution: 3.29 Å
• Binding residue (original residue number in PDB): Q537 G571 L604 R606 T867
• Binding residue (residue number reindexed from 1): Q538 G572 L605 R607 T868
• Annotation score: 5

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Fri Nov 22 23:27:10 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1435     title=pdb2title(pdbid)

   1436     if bs.startswith("BS"):

=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)

   1438     else:

   1439         if lig3:

pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '7zz8', asym_id = 'A', bs = 'BS05', title = 'CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase.'

 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='7zz8', asym_id='A', bs='BS05', title='CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase.')

   1295         display_ec(ec,csaOrig,csaRenu)

   1296     if go:

=> 1297         display_go(go,uniprot,pdbid,asym_id)

   1298     return pubmed,uniprot

   1299 

global display_go = <function display_go>, go = '0003824,0004736,0005524,0006090,0006094,0046872', uniprot = '', pdbid = '7zz8', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0003824,0004736,0005524,0006090,0006094,0046872', uniprot='', pdbid='7zz8', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>