Structure of PDB 7z1o Chain A Binding Site BS05

Receptor Information
>7z1o Chain A (length=1436) Species: 580240 (Saccharomyces cerevisiae W303) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKA
NGALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATI
QILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKK
QRRCLHCGALNGVVKKAAAGAGSAALKIIHDTFRWVGKKSAPEKDIWVGE
WKEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPS
GRPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIK
AGLDKGISINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSVKPIRGFCQR
LKGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPE
KVTRYNRHKLQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNL
QIGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCT
PYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQD
FITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTG
KQVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRG
SQILSGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLG
NRGFSIGINDVTPADDLKQKKEELVEIAYHKCDELITLFNKGELETQPGC
NEEQTLEAKIGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNV
SQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGL
SPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRT
SANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLP
YAIMETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYH
SLREYINGKATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSV
SQLYRISEKSVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPGTQMTL
KTFHFAGVASMNVTLGVPRIKEIINASKVISTPIINAVLVNDNDERAARV
VKGRVEKTLLSDVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIA
VAITRASKLKIQASDVNIIGKDRIAINVFPENDVFYRMQQLRRALPDVVV
KGLPDISRAVINIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEV
FSVLGIEAARYSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGIT
RFGLSKMRDSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMS
IGTGSFKVVKGTNISEKDLVPKRCLFESLSNEAALK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7z1o Chain A Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z1o Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly(dT) termination signals.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		C107 C154
Binding residue
(residue number reindexed from 1)		C107 C154
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7z1o, PDBe:7z1o, PDBj:7z1o
PDBsum7z1o
PubMed36070694
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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