Structure of PDB 7tom Chain A Binding Site BS05

Receptor Information
>7tom Chain A (length=498) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMEKKTLSLCPICLKRIPATILEEDGKIIIKKTCPEHGEFKDIYWGDA
ELYKKFDKYEFIGKIEVTNTKVKNGCPYDCGLCPNHKSTTILANIDVTNR
CNLNCPICFANANKSGKVYEPSFEDIKRMMENLRKEIPPTPAIQFAGGEP
TVRSDLPELIKLARDMGFLHVQLATNGIKLKNINYLKKLKEAGLSTIYLQ
FDGISEKPYLVARGKNLLPIKQKVIENCKKVGFDSVVLVPTLVRGVNDNE
VGGIIRYAAENVDVVRGINFQPVSFTGRVDEKTLLEGRITIPDFIKLVEE
QTDGEITEEDFYPVPSVAPISVLVEKLTNDRKPTLSSHQHCGTSTYVFVD
EDGKLIPITRFIDVEGFLEIVKEKIEEIDVKVLGEIALKLPSLIDLDKAP
KSVNIKKIIDLILSVLKSDYSALAELHYHMLMISCMHFMDAYNFDVKRVM
RCCIHYATPDDRIIPFCTYNTLHRQEVEEKFSIPLEEWKRMHKIGGED
Ligand information
Ligand IDMET
InChIInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKeyFFEARJCKVFRZRR-BYPYZUCNSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CSCC[CH](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCCC(C(=O)O)N
CACTVS 3.341CSCC[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCC[C@@H](C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CCSC
FormulaC5 H11 N O2 S
NameMETHIONINE
ChEMBLCHEMBL42336
DrugBankDB00134
ZINCZINC000001532529
PDB chain7tom Chain A Residue 606 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7tom Discovery, structure and mechanism of a tetraether lipid synthase.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		F106 G144 G145 E146 T172 N173 Q197
Binding residue
(residue number reindexed from 1)		F109 G147 G148 E149 T175 N176 Q200
Annotation score4
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7tom, PDBe:7tom, PDBj:7tom
PDBsum7tom
PubMed35882349
UniProtQ58036|HMPTM_METJA 7,8-dihydro-6-hydroxymethylpterin dimethyltransferase (Gene Name=MJ0619)

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