Structure of PDB 7sr6 Chain A Binding Site BS05

Receptor Information
>7sr6 Chain A (length=566) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKGHIEPSFSPWNS
PVFVIQKKSGKWRMLTDLRAVNALIQPMGPLQPGLPSPAMIPKDWPLIII
DLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTI
CQTFVGRALQPVREKFSDCYIIHYIDDILCAAETKDKLIDCYTFLQAEVA
NAGLAIASDKIQTSTPFHYLGMQIENRKIKPQKIEIRKDTLKTLNDFQKL
LGDINWIRPTLGIPTYAMSNLFSILRGDSDLNSKRILTPEATKEIKLVEE
KIQSAQINRIGPLAPLQLLIFATAHSPTGIIIQNTDLVEWSFLPHSTVKT
FTLYLDQIATLIGQTRLRITKLCGNDPDKIVVPLTKEQVRQAFINSGAWQ
IGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRCEPLENALTVFTDGS
SNGKAAYTGPKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYV
VQATRDVETALIKYSMDDQLNQLFNLLQQTVRKRNFPFYITHIRAHTNLP
GPLTKANEQADLLVSS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7sr6 Chain A Residue 612 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7sr6 Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.
Resolution2.62 Å
Binding residue
(original residue number in PDB)		T467 D468 E496 S515 D516
Binding residue
(residue number reindexed from 1)		T447 D448 E476 S495 D496
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sr6, PDBe:7sr6, PDBj:7sr6
PDBsum7sr6
PubMed35771941
UniProtQ9UQG0|POK11_HUMAN Endogenous retrovirus group K member 11 Pol protein (Gene Name=ERVK-11)

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