Structure of PDB 7ne3 Chain A Binding Site BS05

Receptor Information
>7ne3 Chain A (length=416) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SCRCVIIEKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYT
GKEGKSSQGCPIAKWVVRRSSSEEKLLCLVRERAGHTCEAAVIVILILVW
EGIPLSLADKLYSELTETLRKYGTLTNRRCALNEERTCACQGLDPETCGA
SFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLSTLM
APTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHAHR
DLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVE
AQEEKKRSGAIQVLSSFRRKVRMLAEPVKTCRGSDEVWSDSEQSFLDPDI
GGVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNE
PKHGLALWEAKMAEKA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7ne3 Chain A Residue 2003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ne3 Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		C1289 C1298 C1358 H1912
Binding residue
(residue number reindexed from 1)		C156 C165 C225 H403
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Gene Ontology
Molecular Function
GO:0070579 5-methylcytosine dioxygenase activity
Biological Process
GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7ne3, PDBe:7ne3, PDBj:7ne3
PDBsum7ne3
PubMed36070377
UniProtQ6N021|TET2_HUMAN Methylcytosine dioxygenase TET2 (Gene Name=TET2)

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