Structure of PDB 7mgm Chain A Binding Site BS05

Receptor Information

>7mgm Chain A (length=2274) Species: 4932 (Saccharomyces cerevisiae)

KLTIDSLKMIKSSLSTFLERQRRQFPRFYFLGNDDLLKIIGSGKHHDQVS
KFMKKMFGSIESIIFFEDSITGVRSVEGEVLNLNEKIELKDSIQAQEWLN
ILDTEIKLSVFTQFRDCLGQLKDGTDIEVVVSKYIFQAILLSAQVMWTEL
VEKCLQTNEFSKYWKEVDMKIKGLLDKLNKSSDNVKKKIEALLVEYLHFN
NVIGQLKNCSTKEEARLLWAKVQKFYQKNDTLDDLNSVFISQSGYLLQYK
FEYIGIPERLIYTPLLLVGFATLTDSLHQKYGGCFFGPAGTGKTETVKAF
GQNLGRVVVVFNCDDSFDYQVLSRLLVGITQIGAWGCFDEFNRLDEKVLS
AVSANIQQIQNGLQVGKSHITLLEEETPLSPHTAVFITLNPGYNGRSELP
ENLKKSFREFSMKSPQSGTIAEMILQIMGFEDSKSLASKIVHFLELLSSK
CSSMNHYHFGLRTLKGVLRNCSPLVSEFGEGEKTVVESLKRVILPSLGDT
DELVFKDELSKIFDSNSKAIVQCLKDAGQRSGFSMSEEFLKKCMQFYYMQ
KTQQALILVGKAGCGKTATWKTVIDAMAIFDGHANVVYVIDTKVLTKESL
YGSMLKATLEWRDGLFTSILRRVNDDITGTFKNSRIWVVFDSDLDPEYVE
AMNSVLDDNKILTLPNGERLPIPPNFRILFETDNLDHTTPATITRCGLLW
FSTDVCSISSKIDHLLNKSYEALFELDKLKDLISDSFDMASLTNIFTCSN
DLVHILGVRTFNKLETAVQLAVHLISSYRQWFQNLDDKSLKDVITLLIKR
SLLYALAGDSTGESQRAFIQTINTYFGHDSQELSDYSTIVILSFSSFCSE
IPSVSLEAHEVMRPDIVIPTIDTIKHEKIFYDLLNSKRGIILCGPPGSGK
TMIMNNALRNSSLYDVVGINFSKDTTTEHILSALHRHTNYVTGLTLLPKS
DIKNLVLFCDQINLPKLDKYGSQNVVLFLRQLMEKQGFWKTPENKWVTIE
RIHIVGACNPPTDPGRIPMSERFTRHAAILYLGYPSGKSLSQIYEIYYKA
IFKLVPEFRSYTEPFARASVHLYNECKARYSTGLQSHYLFSPRELTRLVR
GVYTAINTGPRQTLRSLIRLWAYEAWRIFADRLVGVKEKNSFEQLLYETV
DKYLPLGNISSTSLLFSGLLSLDFKEVNKTDLVNFIEERFKTFCDEELEV
PMVIHESMVDHILRIDRALKQVQGHMMLIGASRTGKTILTRFVAWLNGLK
IVQPKIHRHSNLSDFDMILKKAISDCSLKESRTCLIIDESNILETAFLER
MNTLLANADIPDLFQGEEYDKLLNNLRNKTRSLGLLLDTEQELYDWFVGE
IAKNLHVVFTICDPTNNKSSAMISSPALFNRCIINWMGDWDTKTMSQVAN
NMVDVVPMEFTDFIVPEVNKELVFTEPIQTIRDAVVNILIHFDRNFYQKM
KVGVNPRSPGYFIDGLRALVKLVTAKYQDLQENQRFVNVGLEKLNESVLK
VNELLDRSISLVKSLTFEKERWLNTTKQFSKTSQELIGNCIISSIYETYF
GHLNERERGDMLVILKRLLGKFAVKYDVNYRFIDYLVTLDEKMKWLECGL
DKNDYFLENMSIVMNSQDAVPFLLDPSSHMITVISNYYGNKTVLLSFLEE
GFVKRLENAVRFGSVVIIQDGEFFDPIISRLISREFNHAGNRVTVEIGDH
EVDVSGDFKLFIHSCDPSGDIPIFLRSRVRLVHFVTNKESIETRIFDITL
TEENAEMQRKREDLIKLNTEYRLKLKNLEKRLLEELNNSELMVTLNNLKK
EAMNIEKKLSESEEFFPQFDNLVEEYSIIGKHSVKIFSMLEKFGQFHWFY
GISIGQFLSCFKRVFIKTRVDEILWLLYQEVYCQFSTALDKKFKMIMAMT
MFCLYKFDIESEQYKEAVLTMIGVLSESSDGVPKLTNDDLRYLWDYVTTK
SYISALNWFKNEFFVDEWNIADVVANSENNYFTMASERDVDGTFKLIELA
KASKESLKIIPLGSIENLNYAQEEISKSKIEGGWILLQNIQMSLSWVKTY
LHKHVEEHEKFKMFMTCHLTGDKLPAPLLQRTDRVVYEDIPGILDTVKDL
WGSQGVWSVYCTFLLSWFHALITARTRLVPHGFSKKYYFNDCDFQFASVY
LENVLATNSTNNIPWAQVRDHIATIVYGGKIDEEKDLEVVAKLCAHVFCG
SDNLQIVPGVRIPQPLLQQSEEEERARLTAILSNTIEPADSLSSWLQLPR
ESILDYERLQAKEVASSTEQLLQE

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7mgm Chain A Residue 4105

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7mgm Structural basis for cytoplasmic dynein-1 regulation by Lis1.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): T1803 D1848
• Binding residue (residue number reindexed from 1): T294 D339
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0008569 minus-end-directed microtubule motor activity
• GO:0016887 ATP hydrolysis activity
• GO:0045505 dynein intermediate chain binding
• GO:0051959 dynein light intermediate chain binding

Biological Process

• GO:0007018 microtubule-based movement

Cellular Component

• GO:0030286 dynein complex

External links

• PDB: RCSB:7mgm, PDBe:7mgm, PDBj:7mgm
• PDBsum: 7mgm
• PubMed: 34994688
• UniProt: P36022|DYHC_YEAST Dynein heavy chain, cytoplasmic (Gene Name=DYN1)