Structure of PDB 7jl3 Chain A Binding Site BS05

Receptor Information

>7jl3 Chain A (length=650) Species: 9606 (Homo sapiens)

SPFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQG
QKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIV
ENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMF
NYLDQKLGGGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIA
TVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRIC
KDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPKDEESRICKALFLY
TSHLRKYNDALIISEHARMKDALDYLKDFFSNVEIEQDLTQRFEEKLQEL
ESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWI
EGNPKLSFLKPGILTGRGGMTLPAQKCILDAFKGDHNILIATSVADEGID
IAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINM
YKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEKENKKLLCRK
CKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKKRAKIFCARQN
CSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPF

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7jl3 Chain A Residue 2004

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7jl3 Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
• Resolution: 4.2 Å
• Binding residue (original residue number in PDB): C810 C813 C864 C869
• Binding residue (residue number reindexed from 1): C548 C551 C596 C601
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:7jl3, PDBe:7jl3, PDBj:7jl3
• PDBsum: 7jl3
• PubMed: 33373584
• UniProt: O95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)