Structure of PDB 7c4b Chain A Binding Site BS05

Receptor Information
>7c4b Chain A (length=297) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSSMILKYPYRVVDTHEKLKEAVTSLQGARSIALDIEAFCTTDQAKQLG
RISLVQACSDAKPVVFLFDVLTLTPDVFVKDMQSLLSDREIRKLFFDCRR
DVEALSCQLGVKPEGVLDLQVFFTAIQWKLRSVNRRSGMGYVLKSVAGLT
RQEGDSAVQTAMTLGNRPVWDIRPLPDHFLEYAAGDVRHILLLSNYLVGN
KDVPVDVVAVERLTAQYVEHYAVGKPVITEADATPAEVNRAWLERYIGPG
GGCHFCGAKGHTEAECFKKQNGKAKCSFCGEVGHTARNCFKKHPQLL
Ligand information
Ligand IDU
InChIInChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyDJJCXFVJDGTHFX-XVFCMESISA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C1NC(=O)N(C=C1)C2OC(C(O)C2O)COP(=O)(O)O
CACTVS 3.341O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)O)O)O
CACTVS 3.341O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O
FormulaC9 H13 N2 O9 P
NameURIDINE-5'-MONOPHOSPHATE
ChEMBLCHEMBL214393
DrugBankDB03685
ZINCZINC000002123545
PDB chain7c4b Chain A Residue 405 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7c4b Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.
Resolution2.101 Å
Binding residue
(original residue number in PDB)		H305 E309 C310 F311
Binding residue
(residue number reindexed from 1)		H261 E265 C266 F267
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:1990923 PET complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c4b, PDBe:7c4b, PDBj:7c4b
PDBsum7c4b
PubMed33332555
UniProtQ38DE2

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