Structure of PDB 7b0y Chain A Binding Site BS05

Receptor Information
>7b0y Chain A (length=1422) Species: 9825 (Sus scrofa domesticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGCGR
YQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVL
GMEPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKI
NNQLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPL
KSLKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAA
NMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPS
DLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNL
SVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMG
IVQDTLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLW
TGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELI
MGILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHT
IGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQT
FENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIA
VVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEF
FFHAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQV
VQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQE
DLVKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRM
IWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQEN
ATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEM
VGALAAQSLGEPATQMTLNAKNVTLGVPRLKELINISKKPKTPSLTVFLL
GQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVN
VYYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLN
CIFNDDNAEKLVLRIRIMNMDDDVFLRCIESNMLTDMTLQGIEQISKVYM
HLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTS
NDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRG
HLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIM
LGQLAPAGTGCFDLLLDAEKCK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7b0y Chain A Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7b0y Structure of a transcribing RNA polymerase II-U1 snRNP complex.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C111 C114 C154 C184
Binding residue
(residue number reindexed from 1)		C101 C104 C144 C148
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
2.7.7.6: DNA-directed RNA polymerase.
3.1.13.-
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:1990841 promoter-specific chromatin binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0033120 positive regulation of RNA splicing
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7b0y, PDBe:7b0y, PDBj:7b0y
PDBsum7b0y
PubMed33446560
UniProtP11414|RPB1_CRIGR DNA-directed RNA polymerase II subunit RPB1 (Gene Name=POLR2A)

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