Structure of PDB 6z8k Chain A Binding Site BS05

Receptor Information

>6z8k Chain A (length=2158)

MDYQEYQQFLARINTARDACVAKDIDVDLLMARHDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKARSSWKQIMNKKLEPKQINNALVLWEQQFM
INNDLIDKSEKLKLFKNFCGIGKSKPKILDFDDANMYLASLTMMEQSKKI
LSKSNGLKPDNFILNEFGSRIKDANKETYDNMHKIFETGYWQCISDFSTL
MKNILSVSQYNRHNTFRIAMCANNNVFAIVFPATVVYSIIVLHKEEENIF
NPGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPGLFLTTCLLFKHDN
PTLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNSLAISSNVKDYIAE
KFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDIYLSDYDITQKGIK
DNRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEKHHVMVDLAKTILE
IECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLADTSRHNHLRNRIE
NRNNFRRSITTISTFTSSKSCLKIGDFRKEKELQSVKQKKILEVQSRKNY
EMLRNAMPNYTDYISTKVFDRLYELLDKKVLTDKPVIEQIMDMMIDHKKF
YFTFFNKGQKTSKDREIFVGEYEAKMCMYAVERIAKERCKLNPDEMISEP
GDGKLKVLEQKSEQEIRFLVETTRQKNREIDEAIELGKIEKLSLGKAKGL
KMEINADMSKWSAQDVFYKYFWLIALDPILYPQEKERILYFMCNYMDKEL
ILPDELLFNLLDQKVAYQNDIIATMTNQLNSNTVLIKRNWLQGNFNYTSS
YVHSCAMSVYKEILKEAITLLDGSILVNSLVHSDDNQTSITIVQDKMEND
KIIDFAMKEFERACLTFGCQANMKKTYVTNCIKEFVSLFNLYGEPFSIYG
RFLLTSVGDCAYIGPYEDLASRISSAQTAIKHGCPPSLAWVSIAISHWMT
SLTYNMLPGQSNDPIDYFPAENRKDIPIELNGVLDAPLSMISTVGLESGN
LYFLIKLLSKYTPVMQKRESVVNQIAEVKNWKVEDLTDNEIFRLKILRYL
VLDAEMDPSDIMGETSDMRGRSILTPRKFTTAGSLRKLYSFSKYQDRLSS
PGGMVELFTYLLEKPELLVTKGEDMKDYMESVIFRYNSKRFKESLSIQNP
AQLFIEQILFSHKPVIDFSGIRDKYINLGKVTFTEAYRLLMRDLSSLELT
NDDIQVIYSYIILNDPMMITIANTHILSIYGSPQRRMGMSCSTMPEFRNL
KLIHHSPALVLRAYSKNNPDPTEMARDLVHLKEFVENTNLEEKMKVRIAM
NEAEKGQRDIVFELKEMTRFYQVCYEYVKSHKIKVFILPAKSYTTTDFCS
LMQGNLIKDKEWYTVHYLKQILSGGHKAIMQHNATSEQNIAFECFKLITH
FADSFIDSLSRSAFLQLIIDEFSYKDVKVSKLYDIIKNGYNRTDFIPLLF
RTGDLRQADLDKYDAMKSHERVTWNDWINLTITGYNRSITIIGEDNKLTY
AELCLTRKTPENITISGRKLLGSRHGLKFENMSKIQNYYITYRKKDRHQF
VYQIHSHESITRRNEEHMAIRTRIYNEITPVCVVNVAEVDGDQRILIRSL
DYLNNDIFSLSRIKVGLDEFATIKKAHFSKMVSFEGPPIKTGLLDLTELM
KSQDLLNLNYDNIRNSNLISFSKLICCEGSDNINDGLEFLSDDPMNFTEG
EAIHSTPIFNIYYSKRGERHMTYRNAIKLLIERETKIFEEAFTFSENGFI
SPENLGCLEAVVSLIKLLKTNEWSTVIDKCIHICLIKNGMDHMYHSFDVP
KCFMGNPITRDINWVMFREFINSLPGTDIPPWNVMTENFKKKCIALINSK
FSEFTKLM

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6z8k Chain A Residue 2301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6z8k Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
• Resolution: 3.02 Å
• Binding residue (original residue number in PDB): C2064 H2169 D2178 H2182
• Binding residue (residue number reindexed from 1): C1977 H2082 D2091 H2095
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.1.-.-

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0016787 hydrolase activity
• GO:0034062 5'-3' RNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006351 DNA-templated transcription
• GO:0019079 viral genome replication
• GO:0039694 viral RNA genome replication

Cellular Component

• GO:0044165 host cell endoplasmic reticulum
• GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
• GO:0044177 host cell Golgi apparatus
• GO:0044423 virion component

External links

• PDB: RCSB:6z8k, PDBe:6z8k, PDBj:6z8k
• PDBsum: 6z8k
• PubMed: 32681014
• UniProt: A5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)