Structure of PDB 6uv2 Chain A Binding Site BS05

Receptor Information
>6uv2 Chain A (length=431) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVF
AFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGK
TLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCS
RLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTY
LVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFL
RDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKT
IIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPI
LIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTF
FTPGNLKQARELIKVLEEANQAINPKLMQLV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6uv2 Chain A Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6uv2 RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.
Resolution1.894 Å
Binding residue
(original residue number in PDB)		K53 G129 D131 Q272
Binding residue
(residue number reindexed from 1)		K11 G87 D89 Q230
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6uv2, PDBe:6uv2, PDBj:6uv2
PDBsum6uv2
PubMed31851931
UniProtQ92841|DDX17_HUMAN Probable ATP-dependent RNA helicase DDX17 (Gene Name=DDX17)

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