Structure of PDB 6rwn Chain A Binding Site BS05
Receptor Information
>6rwn Chain A (length=270) Species:
11723
(Simian immunodeficiency virus) [
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GFLDGIEKAQEEHEKYHNNWRAMAEDFQIPQVVAKEIVAQCPKCQVKGEA
MHGQVDASPKTWQMDCTHLEGKVIIVAVHVASGYIEAEVLPAETGKETAH
FLLKLAARWPVKHLHTDNGDNFTSSAVQAVCWWAQIEHTFGVPYNPQSQG
VVESMNHQLKTIITQIRDQAEKIETAVQMAVLIHNFKRKGGIGGYSAGER
IIDIIASDLQTTKLQNQISKIQNFRVYFREGRDQQWKGPATLIWKGEGAV
VIQDGQDLKVVPRRKCKIIK
Ligand information
Ligand ID
MG
InChI
InChI=1S/Mg/q+2
InChIKey
JLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mg+2]
CACTVS 3.341
[Mg++]
Formula
Mg
Name
MAGNESIUM ION
ChEMBL
DrugBank
DB01378
ZINC
PDB chain
6rwn Chain A Residue 304 [
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Receptor-Ligand Complex Structure
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PDB
6rwn
Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Resolution
3.1 Å
Binding residue
(original residue number in PDB)
D64 D116
Binding residue
(residue number reindexed from 1)
D65 D117
Annotation score
4
Enzymatic activity
Enzyme Commision number
3.1.13.2
: exoribonuclease H.
3.1.26.13
: retroviral ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676
nucleic acid binding
GO:0008270
zinc ion binding
Biological Process
GO:0015074
DNA integration
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Molecular Function
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Biological Process
External links
PDB
RCSB:6rwn
,
PDBe:6rwn
,
PDBj:6rwn
PDBsum
6rwn
PubMed
32001525
UniProt
E1ANT8
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