Structure of PDB 6pgw Chain A Binding Site BS05

Receptor Information
>6pgw Chain A (length=427) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VFDEPVYTVNVLENSPINTLVIDLNATDPDEGTNGEVVYSFINFVSNLTK
QMFKIDPKTGVITVNGVLDHEELHIHEIDVQAKDLGPNSIPAHCKVIVNV
IDINDNAPEIKLLSENSEMVEVSENAPLGYVIALVRVSDNDSGANGKVQC
RLQGNVPFRLNEFESFSTLLVDGRLDREQRDMYNLTILAEDSGYPPLRSS
KSFAVKVTDENDNPPYFTKPHYQAMVLENNVPGAFLLAVSARDPDLGMNG
TVSYEIIKSEVRGMSVESYVTVNSNGEIYGVRAFNHEDTRTFEFKVSAKD
GGDPPLTSNATVRIVVLDVNDNTPVMTTPPLVNGTAEVSIPKNAGVGYLV
TQIKADDYDEGENGRLTYSISEGDMAYFEIDQINGEVRTTKTFGENAKPS
YQITVVAHDHGQTSLSASAYIVIYLSP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6pgw Chain A Residue 705 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6pgw A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E337 E391 D422 E423 D425 D458
Binding residue
(residue number reindexed from 1)		E124 E178 D209 E210 D212 D245
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6pgw, PDBe:6pgw, PDBj:6pgw
PDBsum6pgw
PubMed34520737
UniProtF8W3X3|PCD19_DANRE Protocadherin-19 (Gene Name=pcdh19)

[Back to BioLiP]