Structure of PDB 6h67 Chain A Binding Site BS05

Receptor Information
>6h67 Chain A (length=1463) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLY
DLALGAFLRNLCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRA
SCLFCHHFRLKSVEVHRYACKLRLLQYGLIDESYKLDEITLSSTLLNELK
SKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGK
CDNCGMFSPKFRKDGFTKIFETALNEKQITNNRVKGSTYILSTEVKNILD
TVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVLVVPPTRFRLPSKVHE
NSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIFSRLMNAFVT
IQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYA
ARSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDK
WPGATQIQNEDGSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYR
HIKNRDVVLMNRQPTLHKASMMGHKVRVLPNEKTLRLHYANTGAYNADFD
GDEMNMHFPQNENARAEALNLANTDSQYLTPTSGSPVRGLIQDHISAGVW
LTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIFKPYPLWTGK
QIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCG
ILDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCG
MDDLRLTAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRL
QEILRDNNKSGILDAVTSSKVNAITSQVVSKCVPDGTMKKFPCNSMQAMA
LSGAKGSNVNVSQIMCLLGQQALEGRRVPVMVSGKTLPSFKPYETDAMAG
GYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLTKQLEG
VHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKK
YNPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNP
AKYLGSVSENFQDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLI
NPGEAVGIIASQSVGEPSTQMTLNTFHFAANVTLGIPRLREIVMTASAAI
KTPQMTLPIWNDVSDEQADTFCKSISKVLLSEVIDKVIVTERSYVIHMRF
FDNNEYSEEYDVSKEELQNVISNQFIHLLEAAIVKEIKKQKKVQRDRQSA
IISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIR
QIPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAV
LKTYGVEAARNTIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFN
RQGMETSTSSFMKMSYETTCQFLTKAVLDNEREQLDSPSARIVVGKLNNV
GTGSFDVLAKVPN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6h67 Chain A Residue 3003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6h67 Structural basis of RNA polymerase I stalling at UV light-induced DNA damage.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		D627 D631
Binding residue
(residue number reindexed from 1)		D548 D552
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:1990841 promoter-specific chromatin binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:0006361 transcription initiation at RNA polymerase I promoter
GO:0006362 transcription elongation by RNA polymerase I
GO:0006363 termination of RNA polymerase I transcription
GO:0042254 ribosome biogenesis
GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6h67, PDBe:6h67, PDBj:6h67
PDBsum6h67
PubMed30127008
UniProtP10964|RPA1_YEAST DNA-directed RNA polymerase I subunit RPA190 (Gene Name=RPA190)

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