Structure of PDB 6bs1 Chain A Binding Site BS05

Receptor Information

>6bs1 Chain A (length=432) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQL
RKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIA
VGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK
EVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKNSVVF
GTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQIL
PNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLL
FSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQ
ELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFA
IAKELLKTEIDADFPHPLRLRLMGVRISSFPN

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

6bs1 Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	6bs1 Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender.
Resolution	3.15 Å
Binding residue (original residue number in PDB)	R352 V354 I357
Binding residue (residue number reindexed from 1)	R266 V268 I271
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding
GO:0003887	DNA-directed DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6bs1, PDBe:6bs1, PDBj:6bs1
PDBsum	6bs1
PubMed	29715472
UniProt	Q9UBT6\|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

[Back to BioLiP]