Structure of PDB 5s85 Chain A Binding Site BS05

Receptor Information
>5s85 Chain A (length=282) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTVARDITLLCVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELY
NTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDT
VSCLRIVLSIASGLAHLHIEIFGGKPAIAHRDLKSKNILVKKNGQCCIAD
LGLAVMHRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARR
MVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTL
TSLAKLMKECWYQNPSARLTALRIKKTLTKID
Ligand information
Ligand IDXK4
InChIInChI=1S/C3H8N2O/c4-3-1-2-6-5-3/h3,5H,1-2,4H2/t3-/m1/s1
InChIKeyIRMAFFLFVPYKOZ-GSVOUGTGSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7C1CONC1N
OpenEye OEToolkits 2.0.7C1CON[C@H]1N
CACTVS 3.385N[C@H]1CCON1
ACDLabs 12.01NC1NOCC1
CACTVS 3.385N[CH]1CCON1
FormulaC3 H8 N2 O
Name(3R)-1,2-oxazolidin-3-amine
ChEMBL
DrugBank
ZINC
PDB chain5s85 Chain A Residue 510 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5s85 XChem group deposition
Resolution1.33 Å
Binding residue
(original residue number in PDB)		V376 F441
Binding residue
(residue number reindexed from 1)		V159 F224
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5s85, PDBe:5s85, PDBj:5s85
PDBsum5s85
PubMed
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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