Structure of PDB 5mwl Chain A Binding Site BS05

Receptor Information

>5mwl Chain A (length=421) Species: 10090 (Mus musculus)

KMDENEWSYHGEGNKSLVVAHAQRCVVLRFLKFPPNKKKTSEEILQHLQN
IVDFGKNVMKDFLGENYVHCGEVVQLPLEFVKQLCLKIQCERPEKDLDTF
SGYAMCLPNLTRLQTFHFAEHRPILCVEIKPKCGFIPFSNDVTHEMKHKV
CRYCMHQHLKVATGKWKKISKYCPLDLYSGNKQRMHFALRSLLQETQNNL
RIFKNGELIYGCPVADLKELAHHLKPFFFPSNGLASGPHCTKAVIRELVH
VITRVLLSSSEKARAGALRLGLQGPRVCEASPGLPKGCLLYKTLQVQMLD
QLDIEGLYPLYKRVEQYLEEFPEERKTLQIDGPYDEVFYQKLLDLSTEDD
GTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQSRLAFSVSVLDLDLKPY
ESIPHQYKLDSKIVNYYSKTV

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5mwl Chain A Residue 505

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5mwl The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): K19 D439
• Binding residue (residue number reindexed from 1): K15 D396
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.1.158: inositol-pentakisphosphate 2-kinase.

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0035299 inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity

Biological Process

• GO:0016310 phosphorylation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:5mwl, PDBe:5mwl, PDBj:5mwl
• PDBsum: 5mwl
• PubMed: 28450399
• UniProt: Q6P1C1|IPPK_MOUSE Inositol-pentakisphosphate 2-kinase (Gene Name=Ippk)