Structure of PDB 5mwb Chain A Binding Site BS05

Receptor Information
>5mwb Chain A (length=118) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDP
CQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVN
RFQCLCPPGFTGPVCQID
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5mwb Chain A Residue 606 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5mwb Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
Resolution1.86 Å
Binding residue
(original residue number in PDB)		D415 V416 E418 N435 T436 A439
Binding residue
(residue number reindexed from 1)		D1 V2 E4 N21 T22 A25
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:5mwb, PDBe:5mwb, PDBj:5mwb
PDBsum5mwb
PubMed28572448
UniProtQ04721|NOTC2_HUMAN Neurogenic locus notch homolog protein 2 (Gene Name=NOTCH2)

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