Structure of PDB 5fj8 Chain A Binding Site BS05

Receptor Information
>5fj8 Chain A (length=1422) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKAN
GALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQ
ILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQ
RRCLHCGALNGVVKKAAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLAH
NPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSGRPETYI
WRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLDKGI
SINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSSNGGGKVKPIRGFCQRL
KGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEK
VTRYNRHKLQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQ
IGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTP
YNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDF
ITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGK
QVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGS
QILSGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGN
RGFSIGINDVTPADDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCN
EEQTLEAKIGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVS
QMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLS
PPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTS
ANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPY
AIMETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHS
LREYINGKATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVS
QLYRISEKSVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPMNVTLGV
PRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKTLLSDVAFYV
QDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASKLKIQASDVN
IIGKDRIAINVFPSENDVFYRMQQLRRALPDVVVKGLPDISRAVINIRDD
GKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSIIRE
INYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLAS
FEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISE
KDLVPKRCLFESLSNEAALKAN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5fj8 Chain A Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5fj8 Molecular Structures of Unbound and Transcribing RNA Polymerase III.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		N109 C110
Binding residue
(residue number reindexed from 1)		N108 C109
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5fj8, PDBe:5fj8, PDBj:5fj8
PDBsum5fj8
PubMed26605533
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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