Structure of PDB 4wxs Chain A Binding Site BS05

Receptor Information

>4wxs Chain A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGT
DVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRT
VIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYS
TDDAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYT
SADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLN
MVTYDIKLS

Ligand information

Ligand ID

InChI

InChI=1S/Na/q+1

InChIKey

FKNQFGJONOIPTF-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Na+]

Formula

Name

SODIUM ION

PDB chain

4wxs Chain A Residue 607 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4wxs Structural basis for misfolding in myocilin-associated glaucoma.
Resolution	1.9 Å
Binding residue (original residue number in PDB)	G326 A327 D380 L381 D478
Binding residue (residue number reindexed from 1)	G83 A84 D137 L138 D235
Annotation score	3

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:4wxs, PDBe:4wxs, PDBj:4wxs
PDBsum	4wxs
PubMed	25524706
UniProt	Q99972\|MYOC_HUMAN Myocilin (Gene Name=MYOC)

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