Structure of PDB 4ogc Chain A Binding Site BS05

Receptor Information
>4ogc Chain A (length=883) Species: 1115803 (Actinomyces naeslundii str. Howell 279) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAHHLRVGIDVGTHSVGLATLRVDDHGTPIELLSALSHIHDSGSAVSRVA
PDPLPGQGSFRRAPKCDPEFQRFRIISIVANLRISETKGENRPLTADERR
HVVTFLTEDSQADLTWVDVAEKLGVHRRDLRGTRSAARPPIDATDRIMRQ
TKISSLKTWWEEADSEQRGAMIRYLYEDPTDSECAEIIAELPEEDQAKLD
SLHLPAGRAAYSRESLTALSDHMLATTDDLHEARKRLFGVDDSWAPPAEA
INAPVGNPSVDRTLKIVGRYLSAVESMWGTPEVIHVEHVRDGFTSERMAD
ERDKANRRRYNDNQEAMKKIQRDYGKEGYISRGDIVRLDALELQGCACLY
CGTTIGYHTCQLDHIVPQAGPGSNNRRGNLVAVCERCNRSKSNTPFAVWA
QKCGIPHVGVKEAIGRVRGWRKQTPNTSSEDLTRLKKEVIARLRRTQEDP
EIDERSMESVAWMANELHHRIAAAYPETTVMVYRGSITAAARKAAGIDSR
INLIGEKGRKDRIDRRHHAVDASVVALMEASVAKTLAERSSLRGEQRLTG
KEQTWKQYTGSTVGAREHFEMWRGHMLHLTELFNERLAEDKVYVTQNIRL
RLSDGNAHTVNPSKLVSHRLGDGLTVQQIDRACTPALWCALTREKDFDEK
NGLPAREDRAIRVHGHEIKSSDYIQVFSKRKKTDSDRDETPFGAIAVRGG
FVEIGPSIHHARIYRVEGKKPVYAMLRVFTHDLLSQRHGDLFSAVIPPQS
ISMRCAEPKLRKAITTGNATYLGWVVVGDELEINVDSFTKYAIGRFLEDF
PNTTRWRICGYDTNSKLTLKPIVLAAEGLENPSSAVNEIVELKGWRVAIN
VLTKVHPTVVRRDALGRPRYSSRSNLPTSWTIE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4ogc Chain A Residue 1206 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ogc Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D17 E505
Binding residue
(residue number reindexed from 1)		D10 E287
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4ogc, PDBe:4ogc, PDBj:4ogc
PDBsum4ogc
PubMed24505130
UniProtJ3F2B0|CAS9_ACTNH CRISPR-associated endonuclease Cas9 (Gene Name=cas9)

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