Structure of PDB 4mdv Chain A Binding Site BS05

Receptor Information
>4mdv Chain A (length=351) Species: 6183 (Schistosoma mansoni) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISEFGITRSLIHSFDPHGKHYRPTIKPTTGFSASADAERLHRSMKGPGTN
ELAIINILARRTNYERQEICQSYKSLYKQDLKDDLKSDTSGDFRKVLCQL
IVDTPYMLAKSLYYAMKGLGTNDRVLIEIFTTLWNDEMKAVADAYKQVLK
DKGSEESERSLVTDMKKETCGDYEYALLSLVQAERDDIPILQLKAIPDKG
VNSIINHELAEADAKDLYASERRITRVICNRTPYQLYLTSEIYFKMYGKT
LLEHIESETSGDYRKLLVAVLRYAIDRPSLIAEWLHDSMAGLGTKDYALM
RLLITRSEIDLQDIMDAYESIYGKSLLNAVKDDTSGDYRRTLCVLMGEIY
N
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4mdv Chain A Residue 405 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4mdv Crystal structure and immunological properties of the first annexin from Schistosoma mansoni: insights into the structural integrity of the schistosomal tegument.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		G306 D346
Binding residue
(residue number reindexed from 1)		G293 D333
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4mdv, PDBe:4mdv, PDBj:4mdv
PDBsum4mdv
PubMed24428567
UniProtC4QH88

[Back to BioLiP]