Structure of PDB 4m8o Chain A Binding Site BS05

Receptor Information
>4m8o Chain A (length=1126) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLT
NMHATLVSQEVTTNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDES
RVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSN
QLFEARKLLRPILQDNANNNVQRNIYNVKVDAKHLIEDIREYDVPYHVRV
SIDKDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFAIATTKPPLKFPDS
AVDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNEN
DEVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIG
FAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIE
LDPELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLN
PDETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETY
VGGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSS
VDKVTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNR
LQPDSIKAERDCASCTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFP
NKNKFSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREA
IVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAK
KMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQM
ARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSML
NYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKE
EGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGD
TLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYE
GQKSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVA
IFSADIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITI
PAALQGVSNPVPRVEHPDWLKRKIAT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4m8o Chain A Residue 1303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4m8o Structural basis for processive DNA synthesis by yeast DNA polymerase epsilon.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		C665 C668 C763
Binding residue
(residue number reindexed from 1)		C612 C615 C703
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4m8o, PDBe:4m8o, PDBj:4m8o
PDBsum4m8o
PubMed24292646
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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