Structure of PDB 4kyr Chain A Binding Site BS05

Receptor Information

>4kyr Chain A (length=208) Species: 3702 (Arabidopsis thaliana)

GSHMMRSPYEYHHDLGMNYTLIRDELIVGSQPQKPEDIDHLKQEQNVAYI
LNLQQDKDIEYWGIDLDSIVRRCKELGIRHMRRPAKDFDPLSLRSQLPKA
VSSLEWAVSEGKGRVYVHSSAGLGRAPGVSIAYMYWFCDMNLNTAYDTLV
SKRPCGPNKGAIRGATYDLAKNDPWKEPFESLPENAFEDIADWERKLIQE
RVRALRGT

Ligand information

• Ligand ID: GLC
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
• InChIKey: WQZGKKKJIJFFOK-DVKNGEFBSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  CACTVS 3.341: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: alpha-D-glucopyranose;
  alpha-D-glucose;
  D-glucose;
  glucose
• ChEMBL: CHEMBL423707
• ZINC: ZINC000003861213
• PDB chain: 4kyr Chain C Residue 4

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4kyr Structure of the Arabidopsis Glucan Phosphatase LIKE SEX FOUR2 Reveals a Unique Mechanism for Starch Dephosphorylation.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): R153 R157 S177 W180
• Binding residue (residue number reindexed from 1): R79 R83 S103 W106
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.3.-

Gene Ontology

Molecular Function

• GO:0019203 carbohydrate phosphatase activity

Biological Process

• GO:0006470 protein dephosphorylation
• GO:0016311 dephosphorylation

External links

• PDB: RCSB:4kyr, PDBe:4kyr, PDBj:4kyr
• PDBsum: 4kyr
• PubMed: 23832589
• UniProt: Q9SRK5|LSF2_ARATH Phosphoglucan phosphatase LSF2, chloroplastic (Gene Name=LSF2)