Structure of PDB 3px0 Chain A Binding Site BS05

Receptor Information

>3px0 Chain A (length=557) Species: 1462 (Geobacillus kaustophilus)

KMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFFLR
PETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLLA
AYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEHL
VRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVDT
KRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPVL
KKTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVRP
ATKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESDW
LIFAADYSQIELRVLAHIAEDDNLMEAFRRDLRRQAKAVNYGIVYGISDY
GLAQNLNISRKEAAEFIERYFESFPGVKRYMENIVQEAKQKGYVTTLLHR
RRYLPDITSRNFNVRSFAERMAMNTPIQGSAADIIKKAMIDLNARLKEER
LQAHLLLQVHDELILEAPKEEMERLCRLVPEVMEQAVTLRVPLKVDYHYG
STWYDAK

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 3px0 Chain A Residue 1

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3px0 Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
• Resolution: 1.73 Å
• Binding residue (original residue number in PDB): D653 Y654 D830
• Binding residue (residue number reindexed from 1): D356 Y357 D511
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0008408 3'-5' exonuclease activity

Biological Process

• GO:0006139 nucleobase-containing compound metabolic process
• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication

External links

• PDB: RCSB:3px0, PDBe:3px0, PDBj:3px0
• PDBsum: 3px0
• PubMed: 22006298
• UniProt: Q5KWC1