Structure of PDB 3jbw Chain A Binding Site BS05

Receptor Information

>3jbw Chain A (length=622) Species: 7955 (Danio rerio)

GGRPRQHLLSLTRRAQKHRLRDLKNQVKTFAEKEEGGDVKSVCLTLFLLA
LRAGNEHKQADELEAMMQGRGFGLHPAVCLAIRVNTFLSCSQYHKMYRTV
KATSGRQIFQPLHTLRNAEKELLPGFHQFEWQPALKNVSTSWDVGIIDGL
SGWTVSVDDVPADTISRRFRYDVALVSALKDLEEDIMEGLRERALDDSMC
TSGFTVVVKESCDGMGDVSEKHGSGPAVPEKAVRFSFTIMSISIRLEGED
DGITIFQEQKPNSELSCRPLCLMFVDESDHETLTAILGPVVAERKAMMES
RLIISVGGLLRSFRFFFRGTGYDEKMVREMEGLEASGSTYICTLCDSTRA
EASQNMVLHSITRSHDENLERYEIWRKNPFSESADELRDRVKGVSAKPFM
ETQPTLDALHCDIGNATEFYKIFQDEIGEVYQKPNPSREERRRWRSTLDK
QLRKKMKLKPVMRMNGNYARRLMTREAVEAVCELVPSEERREALLKLMDL
YLQMKPVWRSTCPSRDCPDQLCQYSYNSQQFADLLSSMFKYRYDGKITNY
LHKTLAHVPEIVERDGSIGAWASEGNESGNKLFRRFRKMNARQSKTFELE
DILKHHWLYTSKYLQKFMEAHK

Ligand information

>3jbw Chain J (length=16)

gatctggcctgtctta

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3jbw Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures.
• Resolution: 4.6 Å
• Binding residue (original residue number in PDB): D730 E731 K732 S743 R756 H817 R870 K953 T955 N956 Y957
• Binding residue (residue number reindexed from 1): D323 E324 K325 S336 R349 H410 R463 K546 T548 N549 Y550

Enzymatic activity

• Enzyme Commision number: 2.3.2.27: RING-type E3 ubiquitin transferase.
  3.1.-.-

Gene Ontology

Molecular Function

• GO:0004519 endonuclease activity
• GO:0043565 sequence-specific DNA binding
• GO:0046872 metal ion binding
• GO:0061630 ubiquitin protein ligase activity

Biological Process

• GO:0033151 V(D)J recombination

External links

• PDB: RCSB:3jbw, PDBe:3jbw, PDBj:3jbw
• PDBsum: 3jbw
• PubMed: 26548953
• UniProt: O13033|RAG1_DANRE V(D)J recombination-activating protein 1 (Gene Name=rag1)