Structure of PDB 3hvr Chain A Binding Site BS05

Receptor Information
>3hvr Chain A (length=660) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARR
AGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD
PGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAV
LDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTW
ELLRLGEEDPKELPLPLSLLDYHASKGRLQGREGGRVAWVADKPIPHTGL
LVPVLTLEDLSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIP
KLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAF
GASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRN
RLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAY
PAELAVGFDAGGRESFRFGGAACAVGGHLLWTLPEAQAGERIPQEVVWDL
LEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVS
VRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRGTPRPLKLVHEAGD
TPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLK
EVDREKLFFV
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain3hvr Chain A Residue 689 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3hvr Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Resolution3.211 Å
Binding residue
(original residue number in PDB)		Y197 R232
Binding residue
(residue number reindexed from 1)		Y195 R228
Annotation score3
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3hvr, PDBe:3hvr, PDBj:3hvr
PDBsum3hvr
PubMed19812667
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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