Structure of PDB 2v01 Chain A Binding Site BS05

PDB	2v01 A Structural Insight Into Lead Neurotoxicity and Calmodulin Activation by Heavy Metals.
Resolution	2.15 Å
Binding residue (original residue number in PDB)	D129 D131 D133 Q135 N137 E140
Binding residue (residue number reindexed from 1)	D125 D127 D129 Q131 N133 E136
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	V35
Catalytic site (residue number reindexed from 1)	V31
Enzyme Commision number	?

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0010856	adenylate cyclase activator activity
GO:0019855	calcium channel inhibitor activity
GO:0019901	protein kinase binding
GO:0031432	titin binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0044325	transmembrane transporter binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding
GO:0072542	protein phosphatase activator activity

	Biological Process
GO:0000086	G2/M transition of mitotic cell cycle
GO:0002027	regulation of heart rate
GO:0005513	detection of calcium ion
GO:0007186	G protein-coupled receptor signaling pathway
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016240	autophagosome membrane docking
GO:0021762	substantia nigra development
GO:0031954	positive regulation of protein autophosphorylation
GO:0032465	regulation of cytokinesis
GO:0035458	cellular response to interferon-beta
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT
GO:0050848	regulation of calcium-mediated signaling
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051592	response to calcium ion
GO:0055117	regulation of cardiac muscle contraction
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0071346	cellular response to type II interferon
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0098901	regulation of cardiac muscle cell action potential
GO:0140056	organelle localization by membrane tethering
GO:0140238	presynaptic endocytosis
GO:1901020	negative regulation of calcium ion transmembrane transporter activity
GO:1901842	negative regulation of high voltage-gated calcium channel activity
GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1905913	negative regulation of calcium ion export across plasma membrane
GO:1990456	mitochondrion-endoplasmic reticulum membrane tethering

	Cellular Component
GO:0000922	spindle pole
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005876	spindle microtubule
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0030017	sarcomere
GO:0031514	motile cilium
GO:0031982	vesicle
GO:0032991	protein-containing complex
GO:0034704	calcium channel complex
GO:0043209	myelin sheath
GO:0044305	calyx of Held
GO:0097225	sperm midpiece
GO:0099523	presynaptic cytosol
GO:1902494	catalytic complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:2v01, PDBe:2v01, PDBj:2v01
PDBsum	2v01
PubMed	17671360
UniProt	P0DP23\|CALM1_HUMAN Calmodulin-1 (Gene Name=CALM1)

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