Structure of PDB 2hpm Chain A Binding Site BS05

Receptor Information
>2hpm Chain A (length=1143) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKFAHLHQHTQFSLLDGAAKLQDLLKWVKETTPEDPALAMTDHGNLFGAV
EFYKKATAMGVKPIIGYEAYVAAESRFDRKRGGYFHLTLLAKDFTGYQNL
VRLASRAYLEGFYEKPRIDREILREHAQGLIALSGCLGAEIPQFILQDRL
DLAEARLNEDLSIFGDRFFIEIQNHGLPEQKKVNQVLKEFARKYGLGMVA
TNDGHYVRKEDARAHEVLLAIQSKTTLDDPERWRFPCDEFYVKTPEEMRA
MLPEAEWGDEPFDNTVEIARMCDVDLPIGDKMVYRIPRFPLGRTEAQYLR
ELTFLGLLRRYPDRITEAFYREVLRLLDERALAEALARVEEKAWEELRKR
EWTAEAILHRALYELSVIERMGFPGYFLIVQDYINWARGHGVSVGPGRGS
AAGSLVAYAVGITNIDPLRFGLLFERFLNPERVSMPDIDTDFSDRERDRV
IQYVRERYGEDKVAQIGTFGSLASKAALKDVARVYGIPHKKAEELAKLIP
VQFGKPKPLQEAELRAEMEKDERIRQVIEVAMRLEGLNRHASVHAAGVVI
AAEPLTDLVPLMRDQEGRPVTQYDMGAVEALGLLKMDFLGLRTLTFLDEA
RRIVKESKGVELDYDRLPLDDPKTFELLSRGETKGVFQLESGGMTATVRG
LKPRRLEDIIALVSLYRPGPMEHIPTYIRRHHGQEPVSYAEFPHAEKYLR
PILDETYGIPVYQEQIMQIASQVAGYSLGEADLLRRAMGKKRVEEMQKHR
ERFVRGAKERGVPEEEANRLFDMLEAFANYGFNKSHAAAYSLLSYQTAYV
KAHYPVEFMAALLSVERHDSDKVAEYIRDARALGIPVLPPDVNRSGFDFK
VVGEEILFGLSAVKNVGEMAARAILEERERGGPFKSLGDFLKRLPEQVVN
KRALESLVKAGALDAFGDRARLLASLEPLLRWAAETRERGRSGLVGLFAE
VEEPPLVEASPLDEITMLRYEKEALGIYVSGHPVLRYPGLREVASCTIEE
LSEFVRELPGKPKVLLSGMVEEVRFTLSDETGALEVVKEDIPLLVLAEVE
RVLAQAVWTLEEVLEAPKALEVEVDHALLDEKGARLKSLLDEHPGSLPVY
LRVLGPFGEALFALREVRVGEEALGLLEAEGYRAYLVPDREVF
Ligand information
Ligand ID3PO
InChIInChI=1S/H5O10P3/c1-11(2,3)9-13(7,8)10-12(4,5)6/h(H,7,8)(H2,1,2,3)(H2,4,5,6)
InChIKeyUNXRWKVEANCORM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O
OpenEye OEToolkits 1.5.0OP(=O)(O)OP(=O)(O)OP(=O)(O)O
ACDLabs 10.04O=P(OP(=O)(O)OP(=O)(O)O)(O)O
FormulaH5 O10 P3
NameTRIPHOSPHATE
ChEMBLCHEMBL1230191
DrugBankDB03896
ZINCZINC000006827739
PDB chain2hpm Chain A Residue 1227 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2hpm The Structure of T. aquaticus DNA Polymerase III Is Distinct from Eukaryotic Replicative DNA Polymerases.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		S426 R452
Binding residue
(residue number reindexed from 1)		S400 R426
Annotation score3
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hpm, PDBe:2hpm, PDBj:2hpm
PDBsum2hpm
PubMed16959569
UniProtQ9XDH5|DPO3A_THEAQ DNA polymerase III subunit alpha (Gene Name=dnaE)

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