Structure of PDB 2e3b Chain A Binding Site BS05

Receptor Information

>2e3b Chain A (length=336) Species: 5451 (Agaricales sp. 'Arthromyces ramosus')

SVTCPGGQSTSNSQCCVWFDVLDDLQTNFYQGSKCESPVRKILRIVFHDA
IGFSPALTAAGQFGGGGADGSIIAHSNIELAFPANGGLTDTIEALRAVGI
NHGVSFGDLIQFATAVGMSNCPGSPRLEFLTGRSNSSQPSPPSLIPGPGN
TVTAILDRMGDAGFSPDEVVDLLAAHSLASQEGLNSAIFRSPLDSTPQVF
DTQFYIETLLKGTTQPGPSLGFAEELSPFPGEFRMRSDALLARDSRTACR
WQSMTSSNEVMGQRYRAAMAKMSVLGFDRNALTDCSDVIPSAVSNNAAPV
IPGGLTVDDIEVSCPSEPFPEIATASGPLPSLAPAP

Ligand information

• Ligand ID: HOA
• InChI: InChI=1S/H3NO/c1-2/h2H,1H2
• InChIKey: AVXURJPOCDRRFD-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: NO
  ACDLabs 10.04: ON
• Formula: H3 N O
• Name: HYDROXYAMINE
• ChEMBL: CHEMBL1191361
• PDB chain: 2e3b Chain A Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2e3b Structures of cyanide, nitric oxide and hydroxylamine complexes of Arthromyces ramosusperoxidase at 100 K refined to 1.3 A resolution: coordination geometries of the ligands to the haem iron
• Resolution: 1.3 Å
• Binding residue (original residue number in PDB): R52 H56
• Binding residue (residue number reindexed from 1): R44 H48
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): R52 H56 H184 L201
• Catalytic site (residue number reindexed from 1): R44 H48 H176 L193
• Enzyme Commision number: 1.11.1.7: peroxidase.

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding
• GO:0140825 lactoperoxidase activity

Biological Process

• GO:0000302 response to reactive oxygen species
• GO:0006979 response to oxidative stress
• GO:0034599 cellular response to oxidative stress
• GO:0042744 hydrogen peroxide catabolic process
• GO:0098869 cellular oxidant detoxification

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:2e3b, PDBe:2e3b, PDBj:2e3b
• PDBsum: 2e3b
• PubMed: 17372351
• UniProt: P28313|PER_ARTRA Peroxidase