Structure of PDB 8ugp Chain 1I Binding Site BS05

Receptor Information

>8ugp Chain 1I (length=126) Species: 9823 (Sus scrofa)

ATINYPEKGPLSPRFRGEHALRRYPGEERCIACKLCEAVCPAQAITIEAE
PRSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYN
KEKLLNNGDKWEAEIAANIQADYLYR

Ligand information

• Ligand ID: SF4
• InChI: InChI=1S/4Fe.4S
• InChIKey: LJBDFODJNLIPKO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: [S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
  CACTVS 3.385: S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
• Formula: Fe4 S4
• Name: IRON/SULFUR CLUSTER
• PDB chain: 8ugp Chain 1I Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ugp High-resolution in situ structures of mammalian respiratory supercomplexes.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): H65 C87 P88 I92 C116 I117 Y118 C119 G120 C122
• Binding residue (residue number reindexed from 1): H19 C40 P41 I45 C66 I67 Y68 C69 G70 C72
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0003954 NADH dehydrogenase activity
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0006120 mitochondrial electron transport, NADH to ubiquinone
• GO:0032981 mitochondrial respiratory chain complex I assembly
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:8ugp, PDBe:8ugp, PDBj:8ugp
• PDBsum: 8ugp
• PubMed: 38811722
• UniProt: A0A286ZUN9