Structure of PDB 6xa1 Chain j Binding Site BS04

Receptor Information

>6xa1 Chain j (length=373) Species: 9606 (Homo sapiens)

NVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTAS
NIGSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKEKKV
NIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGT
LQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVAETAV
QLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDISYGG
ENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLK
ALEMGAVEILIVYENLDIMRYLTPPLLEWFANNYKKFGATLEIVTDKSQE
GSQFVKGFGGIGGILRYRVDFQG

Ligand information

>6xa1 Chain k (length=13)

uccaaacuaauuu

.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6xa1 Selective inhibition of human translation termination by a drug-like compound.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): T32 T58 N61 I62 X63 N67 C127
• Binding residue (residue number reindexed from 1): T22 T48 N51 I52 X53 N57 C117

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003747 translation release factor activity
• GO:0004045 aminoacyl-tRNA hydrolase activity
• GO:0005515 protein binding
• GO:0008079 translation termination factor activity
• GO:0016149 translation release factor activity, codon specific
• GO:0043022 ribosome binding
• GO:1990825 sequence-specific mRNA binding

Biological Process

• GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
• GO:0002184 cytoplasmic translational termination
• GO:0006412 translation
• GO:0006415 translational termination
• GO:0006449 regulation of translational termination
• GO:0006479 protein methylation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0018444 translation release factor complex
• GO:0022626 cytosolic ribosome

External links

• PDB: RCSB:6xa1, PDBe:6xa1, PDBj:6xa1
• PDBsum: 6xa1
• PubMed: 33009412
• UniProt: P62495|ERF1_HUMAN Eukaryotic peptide chain release factor subunit 1 (Gene Name=ETF1)