Structure of PDB 3jag Chain ii Binding Site BS04

Receptor Information

>3jag Chain ii (length=416) Species: 9606 (Homo sapiens)

SAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADE
FGTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEG
KEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSG
ALFGTLQGNTREVLHKFTVDLPKKHGRAAQSALRFARLRMEKRHNYVRKV
AETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVD
ISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGV
EDTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKS
HFTDKETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKG
FGGIGGILRYRVDFQG

Ligand information

>3jag Chain hh (length=12)

ucaaaguuuaag

............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3jag Structural basis for stop codon recognition in eukaryotes.
• Resolution: 3.65 Å
• Binding residue (original residue number in PDB): T32 E55 T58 N61 I62 K63 S64 C127
• Binding residue (residue number reindexed from 1): T27 E50 T53 N56 I57 K58 S59 C122

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003747 translation release factor activity
• GO:0004045 aminoacyl-tRNA hydrolase activity
• GO:0005515 protein binding
• GO:0008079 translation termination factor activity
• GO:0016149 translation release factor activity, codon specific
• GO:0043022 ribosome binding
• GO:1990825 sequence-specific mRNA binding

Biological Process

• GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
• GO:0002184 cytoplasmic translational termination
• GO:0006412 translation
• GO:0006415 translational termination
• GO:0006449 regulation of translational termination
• GO:0006479 protein methylation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0018444 translation release factor complex
• GO:0022626 cytosolic ribosome

External links

• PDB: RCSB:3jag, PDBe:3jag, PDBj:3jag
• PDBsum: 3jag
• PubMed: 26245381
• UniProt: P62495|ERF1_HUMAN Eukaryotic peptide chain release factor subunit 1 (Gene Name=ETF1)