Structure of PDB 8ipa Chain bl Binding Site BS04

Receptor Information
>8ipa Chain bl (length=437) Species: 4565 (Triticum aestivum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSDSHETDKNIEMWKIKKLIKGLESARGNGTSMISLIMPPRDQVSRVTKM
LGDEYGTASNIKSRVNRQSVLGAITSAQQRLKLYNRVPPNGLVLYTGTIV
TDDGKEKKVTIDFEPFKPINASLYLCDNKFHTEALSELLESDDKFGFIIM
DGNGTLFGTLSGNTREVLHKFSVDLPKKHGRGGQSALRFARLRMEKRHNY
VRKTAELATQFFINPATSQPNVAGLILAGSADFKTELSQSDMFDQRLQCK
ILNVVDVSYGGESGFNQAIELSAEILANVKFIQEKKLIGKYFEEISQDTG
KYVFGVDDTLKALEMGAVETLMVWENLDVNRFVLKHSATGEIIIKHLNKE
GEADQSNFRDPSTNAELEVQEKTSLLEWFANEYKKFGCTLEFVTNKSQEG
SQFCRGFGGIGGILRYQLDIRSFDDLDDDEGVYEDSD
Ligand information
>8ipa Chain cl (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aucagaguggcgcagcggaagcguggugggcccauaacccacagguccca
ggaucgaaaccuggcucugauacca
<<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<
<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB8ipa Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D174 G182 S185
Binding residue
(residue number reindexed from 1)		D174 G182 S185
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003747 translation release factor activity
GO:0016149 translation release factor activity, codon specific
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0002184 cytoplasmic translational termination
GO:0006412 translation
GO:0006415 translational termination
GO:0060255 regulation of macromolecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0018444 translation release factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ipa, PDBe:8ipa, PDBj:8ipa
PDBsum8ipa
PubMed38267667
UniProtI3NM28

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