Structure of PDB 8i0w Chain Y Binding Site BS04

Receptor Information

>8i0w Chain Y (length=204) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIY
KGKKFNARKETVQNEVYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTME
HGATRNFQAEKLLEEEEKRVQKEREDEELNNPMKVLENRTKDSKLEMEVL
ENLQELKDLNQRQAHVDFEAMLRQHRLSEEERRRQQQEEDEQETAALLEE
ARKR

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8i0w Chain Y Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8i0w Molecular basis for the activation of human spliceosome
Resolution	3.4 Å
Binding residue (original residue number in PDB)	C43 C46 C80 C83
Binding residue (residue number reindexed from 1)	C42 C45 C79 C82
Annotation score	4

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0000349	generation of catalytic spliceosome for first transesterification step
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0071006	U2-type catalytic step 1 spliceosome

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Cellular Component

External links

PDB	RCSB:8i0w, PDBe:8i0w, PDBj:8i0w
PDBsum	8i0w
PubMed	39068178
UniProt	Q9BW85\|YJU2_HUMAN Splicing factor YJU2 (Gene Name=YJU2)

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