Structure of PDB 8aow Chain X Binding Site BS04

Receptor Information

>8aow Chain X (length=451) Species: 371094 (Chikungunya virus strain S27-African prototype)

PVYVDIDADSAFLKALQRAYPMFEVEPRQVTPNDHANARAFSHLAIKLIE
QEIDPDSTILDIGSAPARRMMSDRKYHCVCPMRSAEDPERLANYARKLAS
AAGKVLDRNISGKIGDLQAVMAVPDTETPTFCLHTDVSCRQRADVAIYQD
VYAVHAPTSLYHQAIKGVRLAYWVGFDTTPFMYNAMAGAYPSYSTNWADE
QVLKAKNIGLCSTDLTEGRRGKLSIMRGKKLEPCDRVLFSVGSTLYPESR
KLLKSWHLPSVFHLKGKLSFTCRCDTVVSCEGYVVKRITMSPGLYGKTTG
YAVTHHADGFLMCKTTDTVDGERVSFSVCTYVPATICDQMTGILATEVTP
EDAQKLLVGLNQTNTMKNYMIPVVAQAFSKWAKECRKDMEDEKLLGVRER
TLTCCCLWAFKKQKTHTVYKRPDTQSIQKVQAEFDSFVVSGLSIPLRTRI
K

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8aow Chain X Residue 605

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8aow Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): D36 H37 S245
• Binding residue (residue number reindexed from 1): D34 H35 S243
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.1.1.-
  2.7.7.-
  2.7.7.19: polynucleotide adenylyltransferase.
  2.7.7.48: RNA-directed RNA polymerase.
  3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
  3.4.22.-
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.1.74: mRNA 5'-phosphatase.
  3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0008174 mRNA methyltransferase activity

Biological Process

• GO:0006396 RNA processing
• GO:0016556 mRNA modification

External links

• PDB: RCSB:8aow, PDBe:8aow, PDBj:8aow
• PDBsum: 8aow
• PubMed: 36913573
• UniProt: Q8JUX6|POLN_CHIKS Polyprotein P1234