Structure of PDB 7zx6 Chain X Binding Site BS04

Receptor Information
>7zx6 Chain X (length=635) Species: 246194 (Carboxydothermus hydrogenoformans Z-2901) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARQNLKSTDRAVQQMLDKAKREGIQTVWDRYEAMKPQCGFGETGLCCRHC
LQGPCRINPFGDEPKVGICGATAEVIVARGLDRSIAAGAAGHSGHAKHLA
HTLKKAVQGKAASYMIKDRTKLHSIAKRLGIPTEGQKDEDIALEVAKAAL
ADFHEKDTPVLWVTTVLPPSRVKVLSAHGLIPAGIDHEIAEIMHRTSMGC
DADAQNLLLGGLRCSLADLAGCYMGTDLADILFGTPAPVVTESNLGVLKA
DAVNVAVHGHNPVLSDIIVSVSKEMENEARAAGATGINVVGICCTGNEVL
MRHGIPACTHSVSQEMAMITGALDAMILDYQCIQPSVATIAECTGTTVIT
TMEMSKITGATHVNFAEEAAVENAKQILRLAIDTFKRRKGKPVEIPNIKT
KVVAGFSTEAIINALSKLNANDPLKPLIDNVVNGNIRGVCLFAGCNNVKV
PQDQNFTTIARKLLKQNVLVVATGCGAGALMRHGFMDPANVDELCGDGLK
AVLTAIGEANGLGGPLPPVLHMGSCVDNSRAVALVAALANRLGVDLDRLP
VVASAAEAMHEKAVALGTWAVTIGLPTHIGVLPPITGSLPVTQILTSSVK
DITGGYFIVELDPETAADKLLAAINERRAGLGLPW
Ligand information
Ligand IDFE2
InChIInChI=1S/Fe/q+2
InChIKeyCWYNVVGOOAEACU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Fe+2]
CACTVS 3.341[Fe++]
FormulaFe
NameFE (II) ION
ChEMBL
DrugBankDB14510
ZINC
PDB chain7zx6 Chain X Residue 704 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7zx6 Substrate Activation at the Ni,Fe Cluster of CO Dehydrogenases: The Influence of the Protein Matrix
Resolution1.447 Å
Binding residue
(original residue number in PDB)		H261 C295 C526
Binding residue
(residue number reindexed from 1)		H260 C294 C525
Annotation score1
Enzymatic activity
Enzyme Commision number 1.2.7.4: anaerobic carbon-monoxide dehydrogenase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004601 peroxidase activity
GO:0016151 nickel cation binding
GO:0016491 oxidoreductase activity
GO:0043885 anaerobic carbon-monoxide dehydrogenase activity
GO:0046872 metal ion binding
GO:0050418 hydroxylamine reductase activity
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0042542 response to hydrogen peroxide
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zx6, PDBe:7zx6, PDBj:7zx6
PDBsum7zx6
PubMed
UniProtQ9F8A8|COOS2_CARHZ Carbon monoxide dehydrogenase 2 (Gene Name=cooS2)

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