Structure of PDB 8fla Chain SR Binding Site BS04

Receptor Information
>8fla Chain SR (length=601) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AHYNFKKITVVPSAKDFIDLTLSKTQRKTPTVIHKHYQIHRIRHFYMRKV
KFTQQNYHDRLSQILTDFPKLDDIHPFYADLMNILYDKDHYKLALGQINI
AKNLVDNVAKDYVRLMKYGDSLYRCKQLKRAALGRMCTVIKRQKQSLEYL
EQVRQHLSRLPTIDPNTRTLLLCGYPNVGKSSFINKVTRADVDVQPYAFT
TKSLFVGHMDYKYLRWQVVDTPGILDHPLEDRNTIEMQAITALAHLRAAV
LYVMDLSEQCGHGLREQLELFQNIRPLFINKPLIVVANKCDVKRIAELSE
DDQKIFTDLQSEGFPVIETSTLTEEGVIKVKTEACDRLLAHRVETKMKGN
KVNEVLNRLHLAIPTRRDDKERPPFIPEGVKKRERDLELEMGDDYILDLQ
KYWDLMNLSEKHDKIPEIWEGHNIADYIDPAIMKKLEELEKEEELRTAAG
EYDSVSESEDEEMLEIRQLAKQIREKKKLKILESKEKNTQGPRMPRTAKK
VQRTVLEKEMRSLGVDMDDKDDAHYAVQARRSRSITRKRTPRDVSGLRDV
KMVKKAKTMMKNAQKKMNRLGKKGEADRHVFDMKPKHLLSGKRKAGKKDR
R
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8fla Chain SR Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fla Principles of human pre-60 S biogenesis.
Resolution2.63 Å
Binding residue
(original residue number in PDB)		S182 T202
Binding residue
(residue number reindexed from 1)		S181 T201
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:1990275 preribosome binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001649 osteoblast differentiation
GO:0008156 negative regulation of DNA replication
GO:0008285 negative regulation of cell population proliferation
GO:0022408 negative regulation of cell-cell adhesion
GO:0030336 negative regulation of cell migration
GO:0031397 negative regulation of protein ubiquitination
GO:0033342 negative regulation of collagen binding
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0050821 protein stabilization
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fla, PDBe:8fla, PDBj:8fla
PDBsum8fla
PubMed37410842
UniProtQ9BZE4|GTPB4_HUMAN GTP-binding protein 4 (Gene Name=GTPBP4)

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