Structure of PDB 8rxx Chain SK Binding Site BS04

Receptor Information

>8rxx Chain SK (length=198) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GIVRSRLHKRKITGGKTKIHRKRMKAELGRLPANTRLGARRVSPVRARGG
NFKIRALRLDTGNFAWASEAIAHRVRLLDVVYNATSNELVRTKTLVKNCI
VAVDAAPFKRWYAKHYGIDLDADKDKYDVNKASPKLQREWTRRRRNHRVE
KAIADQLREGRVLARITSRPGQSGRADGILLEGAELQFYLKRLEKKKK

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

8rxx Chain SK Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8rxx Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution	2.97 Å
Binding residue (original residue number in PDB)	E89 R92
Binding residue (residue number reindexed from 1)	E88 R91
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412	translation

	Cellular Component
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8rxx, PDBe:8rxx, PDBj:8rxx
PDBsum	8rxx
PubMed	38722744
UniProt	P25204\|RS8_LEIMA Small ribosomal subunit protein eS8 (Gene Name=RPS8A)

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