Structure of PDB 3j9z Chain S1 Binding Site BS04

Receptor Information
>3j9z Chain S1 (length=702) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMD
WMEQEQERGITITSAATTAFWSGMAKQYEPHRINIIDTPGAVDFTIEVER
SMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANF
LKVVNQIKTRLGANPVPLQLAIGAEEHFTGVVDLVKMKAINWNDADQGVT
FEYEDIPADMVELANEWHQNLIESAAEASEELMEKYLGGEELTEAEIKGA
LRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDD
GKDTPAERHASDDEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLN
SVKAARERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPD
APIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDE
ESNQTIIAGMGELHLDIIVDRMKREFNVEANVGKPQVAYRETIRQKVTDV
EGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIP
AVDKGIQEQLKAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAF
KEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRGMLKGQESEVTG
VKIHAEVPLSEMFGYATQLRSLTKGRASYTMEFLKYDEAPSNVAQAVIEA
RG
Ligand information
Ligand IDGTP
InChIInChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyXKMLYUALXHKNFT-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
FormulaC10 H16 N5 O14 P3
NameGUANOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL1233147
DrugBankDB04137
ZINCZINC000060094177
PDB chain3j9z Chain S1 Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3j9z Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		I18 D19 G21 K22 T23 T24 T61 K142 D144 S267 F269
Binding residue
(residue number reindexed from 1)		I18 D19 G21 K22 T23 T24 T61 K142 D144 S267 F269
Annotation score4
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3j9z, PDBe:3j9z, PDBj:3j9z
PDBsum3j9z
PubMed26229983
UniProtP0A6M8|EFG_ECOLI Elongation factor G (Gene Name=fusA)

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