Structure of PDB 6rny Chain O Binding Site BS04

Receptor Information
>6rny Chain O (length=338) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVSRPEGVKIIPPQSDRQKIVLQAHNLAHTGREATLLKIANLYWWPNMRK
DVVKQLGRCQQCLITNASNKASGPILRPDRPQKPFDKFFIDYIGPLPPSQ
GYLYVLVVVDGMTGFTWLYPTKAPSTSATVKSLNVLTSIAIPKVIHSDQG
AAFTSSTFAEWAKERGIHLEFSTPYHPQSSGKVERKNSDIKRLLTKLLVG
RPTKWYDLLPVVQLALNNTYSPVLKYTPHQLLFGIDSNTPFANQDTLDLT
REEELSLLQEIRTSLYHPSTPPASSRSWSPVVGQLVQERVARPASLRPRW
HKPSTVLKVLNPRTVVILDHLGNNRTVSIDNLKPTSHQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rny Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		I112 L113 R114 S216 G218 K219 R222 S258 P259 N348 T351
Binding residue
(residue number reindexed from 1)		I75 L76 R77 S179 G181 K182 R185 S221 P222 N311 T314
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:6rny, PDBe:6rny, PDBj:6rny
PDBsum6rny
PubMed31519882
UniProtP14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

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