Structure of PDB 7xd8 Chain M Binding Site BS04

Receptor Information
>7xd8 Chain M (length=624) Species: 11060 (dengue virus type 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGS
ASSMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEP
KEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDE
NKWKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFG
KAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLG
YILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAE
AIFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNME
AQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDCV
VKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHEL
IMKDGRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMY
FHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRV
WIQENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTA
INQVRSLIGNEEYTDYMPSMKRFR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7xd8 Chain M Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7xd8 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		E438 H442 C447 C450
Binding residue
(residue number reindexed from 1)		E172 H176 C181 C184
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7xd8, PDBe:7xd8, PDBj:7xd8
PDBsum7xd8
PubMed36577062
UniProtQ91H74

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