Structure of PDB 8rxx Chain Le Binding Site BS04

Receptor Information
>8rxx Chain Le (length=186) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRAGMKGKVLGKEKKAAIIDARKKAAESRKNRDDKRWKRVLANMDEEKRK
KFHGVGNTAKNSRVRGATRASLLKRTGRKPDAVSMEATIHLSKLLKKKTF
SKRAPLAIKRIKAFVGRLMKTKDNRIDASLNTYIWHKGVKGVPGRVRVLI
QRKSETTEGNKHKHFYTVISNVPVASFKGLTTKTVE
Ligand information
>8rxx Chain L5 (length=122) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuacgucccucuccaaacgagagaacaugcaugggcuggcaugagcggca
ugcuucuccgguggggcucgacgucccgaggcgcugaaccuugaggccug
aaaauucaugcucagggacacc
....<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<...
..............<<..<<.>>..>>....>>>....>>.....>>>..
......>>>>>...>>>>>...
Receptor-Ligand Complex Structure
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PDB8rxx Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		T2 R3 A4 K7 G8 K9 K13 K16 H54 K61 N62 S63 R64 R66 T69 R70 A71 R76 G78 K80 T89 H91 K94 K97 R146 K179 G180 L181 T182
Binding residue
(residue number reindexed from 1)		T1 R2 A3 K6 G7 K8 K12 K15 H53 K60 N61 S62 R63 R65 T68 R69 A70 R75 G77 K79 T88 H90 K93 K96 R145 K178 G179 L180 T181
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rxx, PDBe:8rxx, PDBj:8rxx
PDBsum8rxx
PubMed38722744
UniProtE9AFF2

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