Structure of PDB 8rxh Chain LB Binding Site BS04

Receptor Information
>8rxh Chain LB (length=404) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHCKFEHPRHGHLGFLPRKRSRQIRGRARAFPKDDATQKPHLTSFMVFKA
GMTHIVRDVDRPGSKVNKKEVVEPVTILEAPPMVIVGIVGYRQTPVGLKT
IGTVWAHHTSVEFRRRYYKNWKQSAQLAFSRQKQFANTKEGKVAEARTLN
AFAKKASVIRVIAHTQLRKLRNHRVGVKKAHVQEIQVNGGSVAAKIALAK
SLLEKEVRVDSVFQQSEACDVCSVTKGHGTEGVVKRWGVACLPRKTHRGL
RKVACIGAWHPARVMYTVARAGQHGYHHRTQLNKKIYQIGRSVAVEPNQA
TTTYDLTAKTITPMGGFVGYGTVRNDYVMLKGSVSGPRRRVMTLRRPMAP
QTSRQLKEKIVLKFIDTSSKIGHGRFQTKKEKNQWFGPLKKDRIRREERL
RKER
Ligand information
>8rxh Chain L5 (length=120) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuacgucccucuccaaacgagagaacaugcaugggcuggcaugagcggca
ugcuucuccgguggggcuccgucccgaggcgcugaaccuugaggccugaa
aauucaugcucagggacacu
....<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<...
..............<<.......>>....>>>....>>.....>>>....
....>>>>>...>>>>>...
Receptor-Ligand Complex Structure
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PDB8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		R21 I25 R116 R117 K120 N121 K123 Q124 A126 R172 H174 R175 V176 G177 V178 K179 K180 K227 G228 G230 T231 Q274 Y277 V294 P298 T311 M315 G316 V319 G320 G322 T323 R325 R340 R341 S370 I372 G373 K380 K383 W386 F387 L390 K391 K392 R394
Binding residue
(residue number reindexed from 1)		R20 I24 R115 R116 K119 N120 K122 Q123 A125 R171 H173 R174 V175 G176 V177 K178 K179 K226 G227 G229 T230 Q273 Y276 V293 P297 T310 M314 G315 V318 G319 G321 T322 R324 R339 R340 S369 I371 G372 K379 K382 W385 F386 L389 K390 K391 R393
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
PDBsum8rxh
PubMed38722744
UniProtQ4Q2Q6

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