Structure of PDB 8sr1 Chain K Binding Site BS04

Receptor Information
>8sr1 Chain K (length=236) Species: 243233 (Methylococcus capsulatus str. Bath) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLDKKWLTFALAIYTVFYLWVRWYEGVYGWSAGLDSFAPEFETYWMNFLY
TEIVLEIVTASILWGYLWKTRDRNLAALTPREELRRNFTHLVWLVAYAWA
IYWGASYFTEQDGTWHQTIVRDTDFTPSHIIEFYLSYPIYIITGFAAFIY
AKTRLPFFAKGISLPYLVLVVGPFMILPNVGLNEWGHTFWFMEELFVAPL
HYGFVIFGWLALAVMGTLTQTFYSFAQGGLGQSLCE
Ligand information
Ligand IDWIY
InChIInChI=1S/C4H7F3O/c5-4(6,7)2-1-3-8/h8H,1-3H2
InChIKeyVKRFUGHXKNNIJO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7C(CC(F)(F)F)CO
ACDLabs 12.01FC(F)(F)CCCO
CACTVS 3.385OCCCC(F)(F)F
FormulaC4 H7 F3 O
Name4,4,4-trifluorobutan-1-ol
ChEMBLCHEMBL4438811
DrugBank
ZINCZINC000004290166
PDB chain8sr1 Chain K Residue 311 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8sr1 Product analogue binding identifies the copper active site of particulate methane monooyxgenase
Resolution2.18 Å
Binding residue
(original residue number in PDB)		D156 H160 R165 H231 E237 E238 L239
Binding residue
(residue number reindexed from 1)		D112 H116 R121 H187 E193 E194 L195
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.13.25: methane monooxygenase (soluble).
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0015049 methane monooxygenase [NAD(P)H] activity
GO:0046872 metal ion binding
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8sr1, PDBe:8sr1, PDBj:8sr1
PDBsum8sr1
PubMed38187819
UniProtQ603F1

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