Structure of PDB 8d3p Chain I Binding Site BS04

Receptor Information
>8d3p Chain I (length=218) Species: 272558 (Halalkalibacterium halodurans C-125) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASNEEDRYLMLSGLQHFQFCKRQWALIHIEQQWEENVRTIEGQHLHKKAD
QPFMKEKRGSKLTVRAMPIQSKNLQISGICDVVEFVQDSEGIELSGVSGS
YKAFPVEYKRGKPKKGDEDIVQLVAQAMCLEEMLVCRIDKGYLFYNEIKH
RVEVPITDALRDKVVQMAKEMHHYYENRHTPKVKTGPFCNNCSLQSICLP
KLMNKRSVKRYIEGRLSE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8d3p Chain I Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8d3p PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation.
Resolution4.26 Å
Binding residue
(original residue number in PDB)		D82 E108
Binding residue
(residue number reindexed from 1)		D81 E107
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.12.1: 5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming).
Gene Ontology
Molecular Function
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8d3p, PDBe:8d3p, PDBj:8d3p
PDBsum8d3p
PubMed36272411
UniProtA0A4Y7WTW2

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