Structure of PDB 8a98 Chain H Binding Site BS04

Receptor Information

>8a98 Chain H (length=221) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AFPSRKDAFRAQRKGAKKHRPEIIVIDLKDHVLGRAAAVVAKQLLLGKKI
TVVRCEQLNIAGTEIRNKIKYLQYLRKRKLTNPTKGPFHHRAPSDVFVRT
VRSMLPRYTKRGMKALNSLVAYEGIPPNVVRTGGRVVIPRAQRHVCYRSE
RPYTVLGNMCKHVGWKYSDVVANLEKARVEKASRHHEKQAKLRDAWKSAR
KEALAKMPKHNVEVLKKFGYA

Ligand information

>8a98 Chain 6 (length=71) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

aucgaaucgccaccuacaagacuggagcuugcucccucgaaggcgccaag
uauauucaugaucacaagaca

......<.<<<............<<<<....>>>>......>>>......
..................>..

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8a98 CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
Resolution	2.46 Å
Binding residue (original residue number in PDB)	R11 R14 V131 R132 G134 G135 R136 H145 H187 W197 R201 H211 G220
Binding residue (residue number reindexed from 1)	R10 R13 V130 R131 G133 G134 R135 H144 H186 W196 R200 H210 G219

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0006412	translation
GO:0017148	negative regulation of translation

	Cellular Component
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:8a98, PDBe:8a98, PDBj:8a98
PDBsum	8a98
PubMed	38722744
UniProt	Q4QFG2

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